KIP publications

year 2018
author(s) Katharina Isensee, Niklas Müller, Annemarie Pucci and Wolfgang Petrich
title Towards a quantum cascade laser-based implant for the continuous monitoring of glucose
KIP-Nummer HD-KIP 18-133
KIP-Gruppe(n) F6,F23
document type Paper
source Analyst (2018)
doi 10.1039/C8AN01382A
Abstract (en)

Continuous glucose monitoring enables an improved disease management for people with diabetes. However, state-of-the-art, enzyme-based, minimally invasive sensors loose their sensitivity over time and have to be replaced periodically. Here, we present the in vitro investigation of a quantum cascade laser-based measurement scheme that conceptually should be applicable over elongated periods of time due to its reagent-free nature and may therefore be considered as an approach towards long-term implantation. The method uses a miniaturized optofluidic interface in transflection geometry to measure the characteristic mid-infrared absorption properties of glucose. A glucose sensitivity of 3.2 mg/dL is achieved in aqueous glucose solutions. While this sensitivity drops to 12 mg/dL in the presence of biologically plausible, maximum concentrations of other monosaccharides, it is still well within the medically acceptable range according to Parkes error grid analysis. With a response time of less than five minutes, our sensor should be able to react adequately fast to physiological changes in glucose concentration. Finally, no drift or deterioration were found during an extended, 42 days in vitro experiment. These results underline the potential of this technique for its conceivable applicability in vivo as long-term glucose monitoring implant.

  author   = {Isensee, Katharina and Müller, Niklas and Pucci, Annemarie and Petrich, Wolfgang},
  title    = {Towards a quantum cascade laser-based implant for the continuous monitoring of glucose},
  journal  = {Analyst},
  year     = {2018},
  volume   = {},
  pages    = {},
  doi      = {10.1039/C8AN01382A},
  url      = {!divAbstract}
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