| year | 2011 |
| author(s) | Christian Vrančić, Anna Fomichova, Norbert Gretz, Carina Herrmann, Sabine Hoecker, Annemarie Pucci & Wolfgang Petrich |
| title | Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopy in vitro |
| KIP-Nummer | HD-KIP 11-08 |
| KIP-Gruppe(n) | F23 |
| document type | Paper |
| Keywords (shown) | mid-infrared transmission spectroscopy, continuous glucose monitoring, fiber spectroscopy |
| source | Analyst 136, 1192 - 1198 (2011) |
| Abstract (en) | The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed. |
| bibtex | @article{vrancic11,
author = {Vrančić, C and Fomichova, A and Gretz, N and Herrmann, C and Hoecker, S and Pucci, A and Petrich, W},
title = {Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopy in vitro},
journal = {Analyst},
volume = {136},
year = {2011},
pages = {1192 - 1198}
} |
| URL | DOI |
