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- Computersimulation of genome aberrations and pathology:

    (Figure: G. Kreth: Zellkernmodelle -
    models of cell nuclei)
For the developement of models regarding nuclear organisation and genomic pathology in interphse, computer simulations have been performed. For this purpose each chromosome of the diploid chromosome set of a genome was described by a linear polymer chain. (e.g. 46 chains for the human genome). Monte Carlo and Brownian Dynamics techniques were applied to calculate thermodynamic equilibrium states and time series of the chromosome chains. Virtual microscopy techniques, obtained from the simulated configurations, allowed then the application of digital image analyis algorithms. An improved interpretation of real image stacks becomes possible then.




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