Biocomputing

- Computersimulation of genome abberations and pathology:

For the developement of models regarding nuclear organisation and genomic pathology in interphse, computer simulations are being performed. For this purpose each chromosome of the diploid chromosome set of a genome is described by a linear polymer chain. (e.g. 46 chains for the human genome). Monte Carlo and Brownian Dynamics techniques are applied to calculate thermodynamic equilibrium states and time series of the chromosome chains. Virtual microscopy techniques, obtained from the simulated configruations, allow then the application of digital image analyis algorithms. Am improved interpretation of real image stacks becomes possible then. For the simulations, a cluster of high-performance computers as well as connections to local and international computation centres are available.
(Figure: G. Kreth 2005: Zellkernmodelle - models of cell nuclei)

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